Health Care Antifungal Ciclopirox Raw Material Ciclopirox

• Customization: Available
• Powder: Yes
• Customized: Negotiable
• Model NO.: QS-Ciclopirox
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Product Name: Ciclopirox
• Name: Ciclopirox Powder
• Appearance: White Powder
• Colour: White
• Grade: Pharmaceutical Grade
• Assay: >99%
• Application: API
• Specific: COA
• Test Method: HPLC
• Density: 1.7400
• CAS: 41621-49-2
• Mf: C14h24n2o3
• MW: 268.35196
• Melting Point: 144c
• Boiling Point: 350c at 760 Mmhg
• Transport Package: Negotiable
• Specification: >99%
• Trademark: QS-Ciclopirox
• Origin: Xian
• Production Capacity: 500kg/Month

Product Description

Health Care Antifungal Ciclopirox Raw Material Ciclopirox

Product Description

Product Details

Product Name	Ciclopirox
Appearance	Ciclopirox Powder
Assay	>99%
MW	268.35196
MF	C14H24N2O3
Melting point	144C
Boiling point	350C at 760 mmHg

Ciclopirox is a synthetic antifungal agent, commonly used in its salt form (ciclopirox olamine or ciclopirox ) for the treatment of superficial fungal infections such as athlete's foot, ringworm, and cutaneous candidiasis. It exerts its antifungal effects by chelating metal ions (e.g., iron), inhibiting fungal metabolic enzyme activity, disrupting cell membrane function, and potentially inducing ferroptosis while suppressing ATPase activity. It is typically administered topically as a cream or solution.

Application&Function

Ciclopirox is a synthetic antifungal agent widely used clinically in its salt form (ciclopirox olamine or ciclopirox ). Below are key pharmacological details:

I. Mechanism of Action
Metal Ion Chelation
Binds to iron and other metal ions, inhibiting fungal metabolic enzymes (e.g., cytochrome P450-dependent enzymes), disrupting cell membrane function and energy metabolism.
Induction of Ferroptosis
May enhance pathogen eradication by triggering ferroptosis, an iron-dependent form of cell death.
ATPase Inhibition
Suppresses fungal ATPase activity, disrupting transmembrane ion gradients and leading to cell death.
II. Antimicrobial Spectrum
Effective against dermatophytes (e.g., Trichophyton spp.), Candida spp., and molds.
Also exhibits activity against some Gram-positive (e.g., Staphylococcus) and Gram-negative bacteria (e.g., E. coli).
III. Indications
Superficial Fungal Infections:
Includes athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), pityriasis versicolor, and cutaneous candidiasis.
Potential Research Applications:
Some studies suggest anti-inflammatory and anticancer properties, though further validation is needed.
IV. Dosage Forms & Usage
Formulations: Typically administered as topical creams, solutions, or lotions.
Precautions: Avoid contact with eyes or open wounds; follow medical guidance for application site and treatment duration.

Specification