Bulk Calcium Folinate API Calcium Folinate
Product Description
Product Details
| Product Name |
Calcium Folinate |
| Appearance |
Calcium Folinate Powder |
| Assay |
>99% |
| MW |
511.508 |
| MF |
C20H21CaN7O7 |
| Melting point |
240-250C |
| Boiling point |
N/A |
Calcium folinate, chemically known as N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)
methyl]amino]benzoyl-L-glutamic acid calcium salt, is an organic compound with the chemical
formula C20H21CaN7O7.
Application&Function
Calcium folinate CAS NO 1492-18-8 is an antidote of the folic acid antagonists. At room temperature, Calcium folinate CAS NO 1492-18-8 appears as yellowish white to yellow crystalline or amorphous powder, being odorless. It is easily soluble in water, but almost insoluble in ethanol or ether, and easily soluble in solution. Calcium folinate is a formylated derivative of folic acid, acting similarly to folic acid, being the activated form of folic acid in the body.
1. Calcium Folinate CAS NO 1492-18-8 is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.);
2. Calcium Folinate CAS NO 1492-18-8 can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate.
3. The megaloblastic anemia caused by folic acid deficiency.
4. In combination with fluorouracil, Calcium Folinate CAS NO 1492-18-8 is used for the treatment of advanced colon cancer and rectal cancer.
Calcium Folinate CAS NO 1492-18-8 is used for the rescue of the toxicity reaction caused by excessive amount of aminopterin and methotrexate as well as being used for the treatment of giant red blood cell anemia.
The efficacy of folate can offset the effects of folic acid antagonists. The folic acid antagonists rely on binding to folic acid dehydrogenase (DHFR), thereby preventing folate from converting to folic acid. Medically, after the chemotherapy of methotrexate, the Calcium folinate CAS NO 1492-18-8 can be used to reduce methotrexate toxicity. Calcium folinate can be used to enhances the cytotoxic effect of 5-fluorouracil in anticancer fields.
Specification
){kind=link}