Antidepressant Trazodone Hydrochloride Powder Trazodone

• Customization: Available
• CAS No.: 19794-93-5
• Formula: C19h22cln5o
• Model NO.: QS-Trazodone
• EINECS: 243-317-1
• Packaging Material: Negotiable
• Storage Method: Normal
• Shelf Life: 2year
• Nutrient Composition: Trazodone
• Resource: Trazodone
• The content of active substances: 99%
• Product Name: Trazodone
• Name: Trazodone Powder
• Assay: HPLC 99%
• Specific: COA
• CAS: 19794-93-5
• Appearance: White Powder
• Color: White
• Mf: C19h22cln5o
• MW: 371.86
• Melting Point: 86-870c
• Boiling Point: 528.5
• Density: 1.3141
• Test Method: HPLC
• Grade: Pharmaceutical Grade
• Application: Antidepressant
• Transport Package: Negotiable
• Specification: 99%
• Trademark: QS
• Origin: Shaanxi Xi′an
• Production Capacity: 1000kg/Month

Product Description

Antidepressant Trazodone Hydrochloride Powder Trazodone

Product Description

Product Detials

Product Name	Trazodone
Apperance	White crystalline powder
CAS	19794-93-5
MF	C19H22ClN5O
MW	371.87

Trazodone hydrochloride is a triazolopyridine derivative classified as a serotonin antagonist and reuptake inhibitor (SARI). First developed in the 1960s and approved by the FDA in 1981, it is chemically designated as 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride. The compound appears as a white to off-white crystalline powder that is soluble in water and organic solvents.

Application&Function

Primary Indications
Major Depressive Disorder (MDD): Modest efficacy as monotherapy; often adjunctive to SSRIs.
Insomnia: Low doses (25–100 mg) improve sleep latency and maintenance via 5-HT2A blockade.
2. Off-Label Uses
Anxiety Disorders: Augments SSRIs in generalized anxiety/social phobia.
PTSD: Reduces nightmares and hyperarousal.
Fibromyalgia/Chronic Pain: Potentiates analgesia via serotonin modulation.
3. Neuropharmacology
5-HT2A Antagonism: Sedation, reduced REM sleep.
Weak SRI: Mild elevation of synaptic serotonin (less than SSRIs).
α1-Adrenergic Blockade: Contributes to orthostatic hypotension.
4. Clinical Advantages
Sleep-Friendly: Unlike SSRIs (which disrupt sleep), trazodone promotes restorative sleep.
Low Sexual Dysfunction: Unlike SSRIs/SNRIs, it rarely causes libido loss.
Geriatric Utility: Minimal anticholinergic/cognitive effects.
5. Side Effects & Risks
Common: Drowsiness, dizziness, dry mouth, headache.
Serious (Rare): Priapism (requiring emergency care), QT prolongation, hepatotoxicity.
Contraindications: Concurrent MAOI use, history of priapism.

Specification

Certificate of Analysis