| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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| Product Name | Rifampicin |
| Appearance | red powder |
| CAS NO | 13292-46-1 |
| MW | 822.94 |
| MF | C43H58N4O12 |
Rifampicin is well absorbed orally and reaches its peak blood concentration within 1.5 to 4 hours after taking the medication. After a single oral dose of 600mg for adults, the peak blood concentration (cmax) is 7-9 mg/L. For children aged 6 months to 5 years, a single oral dose of 10mg/kg results in a peak blood concentration (cmax) of 11mg/L. This product is well distributed in most tissues and body fluids, including cerebrospinal fluid. When there is inflammation in the meninges, the drug concentration in the cerebrospinal fluid increases; Effective therapeutic concentrations can also be achieved in saliva; This product can cross the placenta. The apparent volume of distribution (Vd) is 1.6L/kg. The protein binding rate is 80% to 91%. Taking medication after eating can reduce drug absorption by 30%. The blood elimination half-life (t1/2) of the drug is 3-5 hours, which is shortened to 2-3 hours after multiple administrations.
This product can be rapidly deacetylated by self induced microsomal oxidase in the liver, becoming a metabolite with antibacterial activity called deacetylated rifampicin. After hydrolysis, it forms an inactive metabolite that is excreted in the urine. This product is mainly excreted through the gallbladder and intestines and can enter the enterohepatic circulation, but its deacetylated active metabolites do not have enterohepatic circulation. 60% to 65% of the administered dose is excreted through feces, 6% to 15% of the drug is excreted in its original form, 15% is excreted as an active metabolite through urine, and 7% is excreted as an inactive 3-formyl derivative. It can also be excreted through breast milk. There is no accumulation of this product in patients with renal dysfunction; Due to the self induced action of liver microsomal oxidase, the excretion rate of rifampicin increases after 6-10 days of administration; After using high doses, the excretion of the product may be delayed due to saturation of biliary excretion. Rifampicin cannot be cleared through hemodialysis or peritoneal dialysis.
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