| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Negotiable |
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| Product name | Aminophylline |
| CAS | 317-34-0 |
| WM | 420.426 |
| WF | C16H24N10O4 |
| Purity | 99% |
Pharmacological action
Aminophylline is a compound salt of theophylline, and its basic pharmacological action mainly comes from theophylline, enhances its water solubility.
1, relax bronchial smooth muscle, can also relax the intestinal tract, biliary tract and other smooth muscle, on bronchial mucosa congestion, edema also has a relieving effect.
2. Increase cardiac output, expand the output and input renal arterioles, increase glomerular filtration rate and renal blood flow, and inhibit the reabsorption of sodium and chloride ions by distal renal tubules.
3, increase the contractility of isolated skeletal muscle; Improve muscle contractions in the case of chronic obstructive pulmonary disease. Theophylline is thought to increase ventilatory dysfunction during hypoxia because it increases diaphragmatic contractions, and its role in this area exceeds that of the respiratory center.
pharmacokinetics
This product can be quickly absorbed by oral administration, rectal administration or extraterritorially. In the body aminophylline releases theophylline, which has a protein binding rate of 60%. The volume of distribution (Vd) is about 0.5L/kg. The half-life is 3 to 9 hours. When 6mg/kg aminophylline is injected in half an hour, its blood concentration can reach 10mg/L, and its biological conversion rate in vivo varies between individuals. Oral administration of this product in the fasting state, the peak blood concentration in 2 hours. Most of this product is excreted through the kidney in the form of metabolites, 10% is excreted in its original form.
indication
1, bronchial asthma and asthma-like bronchitis, combined with β-receptor agonists can improve the efficacy. In the persistent state of asthma, aminophylline and adrenal cortex hormone are often used for treatment.
2, the treatment of acute cardiac insufficiency and heart failure of asthma (cardiogenic asthma).
3. Biliary colic.
4. Treatment of sick sinus complex syndrome and sinus block.
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