Purpose
Florfenicol is less likely to develop resistance: As the hydroxyl group in the molecular structure of thiamphenicol is replaced by a fluorine atom, the problem of resistance to chloramphenicol and thiamphenicol is effectively solved. Strains resistant to thiamphenicol, chloramphenicol, amoxicillin and quinolones remain sensitive to this product. Chloramphenicol is prohibited in the production of food animals because it has serious adverse reactions such as causing aplastic anemia and immunosuppression. Research has proved that the main group causing aplastic anemia in the chemical structure of chloramphenicol is the para-nitro group on the aromatic ring. Florfenicol, on the other hand, replaces the NO2 group with CH3SO4, altering its chemical structure. Therefore, it does not cause the adverse reaction of aplastic anemia when used in animals. Therefore, it has been approved for use in more than ten countries including Japan, Mexico and China. Florfenicol is characterized by a broad antibacterial spectrum and is sensitive to Salmonella, Escherichia coli, Proteus, Haemophilus, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Streptococcus suis, Pasteurella suis, Bordetella bronchopulae, Staphylococcus aureus, etc. This drug is easily absorbed, widely distributed in the body, and is a fast-acting and long-acting preparation. It has no potential risk of causing aplastic anemia and is relatively safe. In addition, the price is moderate, cheaper than other drugs for preventing and treating respiratory diseases such as tylosin (mycoplasma), tilmicosin, azithromycin, etc., and the cost of medication is easily acceptable to users. Due to these characteristics, domestic florfenicol has been widely used and has become the preferred drug for the prevention and treatment of bacterial infections in the respiratory and digestive tracts of livestock and poultry at present. Florfenicol should not be used in combination with quinolones, penicillins or cephalosporins, nor should it be compatible with ampicillin, sulfonamides or furans.
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