| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Negotiable |
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| Product Name | Enoxaparin Sodium |
| Appearance | White Powder |
| CAS No | 679809-58-6 |
| MF | C57H82N4Na4O53S3 |
| MW | 288.428 |
Pharmacological action
Much more than regular heparin. The clinical application showed that its anti-X a activity was strong and durable, while the effect of prolonged APTT was weak. Therefore, it showed the characteristics of strong anti-thrombotic effect and small bleeding risk. In addition, Dapheparin sodium can also promote fibrinolysis, protect endothelial cells by binding with vascular endothelial cells, enhance anti-thrombotic effect, and have less influence on platelet function and lipid metabolism than ordinary heparin.
pharmacokinetics
Dapheparin sodium can not be absorbed orally, but takes effect 3 minutes after intravenous injection, the maximum effect time is 2 ~ 4h, and the half-life is about 2h. It takes effect 2 ~ 4h after subcutaneous injection, the maximum effect time is 3min, the peak time is 3 ~ 4h, the half-life is about 3 ~ 5h, the bioavailability is 87%, and the effect can be maintained 10 ~ 24h after multiple administration. The therapeutic concentration of anti-xa required for full antithrombotic activity in plasma fluctuates between 0.1 and 0.6U/ml. For the prevention of left ventricular thrombosis in patients with acute anterior myocardial infarction, the blood concentration of dapheparin sodium against -xa was 0.6-1.0 U/ml. The mean concentration of anti-xa required for the treatment of acute venous thrombosis was 0.5U/ml. Dapheparin sodium is less widely distributed in the body than unfractionated heparin, and its volume of distribution (Vd) is 40-60 ml/kg or 3-11 L. Sodium dapheparin is mainly excreted by the kidney, and its renal clearance rate is 20 to 30ml per minute, and the half-life of patients with renal insufficiency can be prolonged.
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