Pain Reliever Articaine HCl Base Articaine Hydrochloride

• Customization: Available
• CAS No.: 23964-57-0
• Formula: C13h21cln2o3s
• Model NO.: QS-Articaine HCl
• EINECS: 245-957-7
• Packaging Material: Negotiable
• Storage Method: Normal
• Shelf Life: 2year
• Nutrient Composition: Articaine HCl
• Resource: Articaine HCl
• The content of active substances: 99%
• Product Name: Articaine HCl
• Name: Articaine HCl Powdr
• CAS No: 23964-57-0
• Appearance: White or Almost White Powder
• Color: White
• Assay: 99%
• MW: 320.832
• Mf: C13h21cln2o3s
• Melting Point: 173-180 ° C
• Boiling Point: 440.6 ° C
• Density: 1.178 g/cm3
• Flash Point: 220.3 ° C
• Storage Temperature: 2-8 ° C
• Solubility: 20mg/Ml
• pH: 5
• Transport Package: Negotiable
• Specification: >99%
• Trademark: QS
• Origin: Xian
• Production Capacity: 2500kg/Month

Product Description

Pain Reliever Articaine HCl Base Articaine Hydrochloride

Product Description

Product Detials

Product Name	Articaine HCl
Apperance	White  powder
CAS	23964-57-0
MF	C13H21ClN2O3S
MW	320.84

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Articaine HCl appears as a white to almost white crystalline powder. It is freely soluble in water and ethanol, with a melting point range of 149–153°C (with decomposition). Its aqueous solutions exhibit a slightly acidic pH (4.5–6.0 for a 1% solution) and an optical rotation of +30° to +35° in water. The presence of a thiophene ring increases its stability and resistance to hydrolysis, making it suitable for formulations with extended shelf life.

Application&Function

1. Rapid Onset and Prolonged Duration
Onset: Achieves anesthesia within 1–3 minutes of administration, faster than lidocaine or mepivacaine.
2. Enhanced Tissue Penetration
The thiophene ring and ester structure enable superior diffusion through dense tissues (e.g., periodontal ligaments and palatal mucosa), making it ideal for infiltration anesthesia in areas where nerve blocks are challenging.
3. Clinical Applications
Dental Use:

Inferior Alveolar Nerve Block: Effective for mandibular molars and premolars.
Supraperiosteal Infiltration: Successfully anesthetizes maxillary teeth without requiring palatal injections.
Surgical Use:

Minor soft tissue procedures (e.g., biopsies, suturing) in dermatology and plastic surgery.
4. Safety and Tolerability
Low Systemic Toxicity: Metabolized primarily by plasma esterases, reducing hepatic and renal burden.
Side Effects:

Common: Transient numbness, mild swelling, or bruising at the injection site.
Rare: Allergic reactions (rash, anaphylaxis) or methemoglobinemia (extremely rare).
Contraindications: Hypersensitivity to amide anesthetics or sulfites (in epinephrine-containing formulations).

Specification

Certificate of Analysis