N-Acetyl-D-Glucosamine (NAG) is a key precursor for the body's synthesis of glycosaminoglycans (e.g., hyaluronic acid, chondroitin sulfate). It is primarily used to assist in relieving joint pain and stiffness caused by osteoarthritis, repairing skin and mucous membranes (e.g., oral mucosal ulcers, vaginal mucosal damage), and protecting intestinal barrier function, exerting effects by supplementing raw materials for biosynthesis. In the field of joint health, it provides raw materials for chondrocytes, promotes the synthesis of hyaluronic acid and proteoglycans, repairs damaged cartilage matrix, and simultaneously inhibits the activity of cartilage-degrading enzymes (e.g., matrix metalloproteinases) to delay cartilage degeneration and alleviate pain caused by joint friction. In terms of mucosal repair, it is a structural component of mucosal epithelial cells, promoting mucosal cell proliferation and the formation of tight junctions, accelerating the healing of ulcerated wounds, and reducing mucosal inflammatory responses. In intestinal health, it enhances the connection strength between intestinal epithelial cells, prevents the penetration of harmful substances, and assists in improving intestinal barrier damage caused by irritable bowel syndrome, inflammatory bowel disease, etc. Compared with other joint health ingredients (e.g., chondroitin sulfate), it can function independently or synergistically enhance the effects of other components. It is well absorbed orally, has high safety, and has extremely few adverse reactions at conventional doses (occasional mild gastrointestinal discomfort), making it a common substance for the auxiliary management of joint, mucosal, and intestinal health. However, it should be noted that individuals allergic to seafood (as it is often extracted from shrimp and crab shells) should use it with caution.
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