Pharmaceutica CAS 93413-69-5 Venlafaxine Hydrochloride Venlafaxine
Product Description
Product Details
| Product Name |
Venlafaxine |
| Appearance |
Venlafaxine Powder |
| Assay |
>99% |
| MW |
277.408 |
| MF |
C17H27NO2 |
| Melting Point |
72-74C |
| Boiling point |
397.6 ° |
Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain.
A comparative meta-analysis of 12 major antidepressants found that venlafaxine, mirtazapine, escitalopram, and sertraline were significantly more efficacious than duloxetine, fluoxetine, fluvoxamine, paroxetine, and reboxetine. A combination of venlafaxine and mirtazapine achieved remission rates (defined as a HAM-D score of 7 or less) of 58% in one controlled trial. In combination with an antipsychotic medicine aripiprazole, better results in treatment resistant depression in older adults have been demonstrated.
Application&Function
Pharmacological action
Venlafaxine works by inhibiting the reuptake of serotonin (5-HT) and norepinephrine (NA), and also has a certain inhibitory effect on the reuptake of dopamine. It has no affinity for cholinergic receptors, histamine receptors, and A 2 receptors in vitro. Venlafaxine is well absorbed in the gastrointestinal tract and is mainly metabolized by the cytochrome P450 1A2 enzyme in the liver. The half-life of the main active metabolite is 5-11 hours, and it usually reaches a steady-state concentration after 3 weeks.
Specification
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