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Product Description


Product Details

Product Name |
Indomethacin |
Apperance |
White to yellow crystalline powder |
CAS |
53-86-1 |
MF |
C19H16ClNO4 |
MW |
357.79 g/mol |
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID), chemically named 2-methyl-1- (4-chlorobenzoyl) -5-methoxy-1H-indole-3-acetic acid, with the molecular formula C19H16ClNO4. It has significant anti-inflammatory, analgesic, and antipyretic effects, reducing prostaglandin synthesis by inhibiting cyclooxygenase (COX). Indomethacin is usually a white to slightly yellow crystalline powder, slightly soluble in water and easily soluble in organic solvents. It has good stability, but needs to be stored away from light. This active pharmaceutical ingredient is widely used in pharmaceutical preparations such as capsules, suppositories, and injections, and is suitable for various inflammatory diseases.
Application&Function
Indomethacin is mainly used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute attacks of gout, which can alleviate pain and inflammation. In addition, it is also used to treat patent ductus arteriosus in premature infants (by inhibiting prostaglandins to promote catheter closure). Due to its strong gastrointestinal irritation, it is usually recommended to use it for a short period of time or in combination with gastroprotective drugs. In the field of scientific research, indomethacin is used as a COX inhibitor for the study of inflammatory mechanisms. Please note that long-term use may increase cardiovascular and digestive risks, and medication should be taken according to medical advice.