| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Negotiable |
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| Product name | Famciclovir |
| Cas number | 104227-87-4 |
| Apperance | White Powder |
| MF | C14H19N5O4 |
| MW | 321.337 |
pharmacokinetics
Famciclovir is rapidly absorbed orally with a bioavailability of 77% and is quickly conveyed in the body to penciclovir with a t1/2 time of about 2 hours and about 60-65% excreted through the kidney. Cells infected with varicella-zoster virus have a longer half-life (9-10 hours), while those infected with HSV-1 and HSV-2 have intracellular half-lives of 10 and 20 hours, respectively.
Action mechanism
After entering the human body, it is rapidly transformed into peniclovir, which can be phosphorylated into OCV monophosphate by the thymidine kinase encoded by the virus, and then phosphorylated into peniclovir triphosphate by the host. The triphosphate is formed rapidly in the cells infected by the virus, and is metabolized slowly, resulting in prolonged half-life, and participates in the competition of HBV DNA-p guanosine triphosphate (Pgtp). It enters DNA, acts on the initiation and extension steps of DNA synthesis, inhibits DNA synthesis, and has a strong inhibitory effect on varicella-zoster virus, herpes simplex virus type 1 and type 2 and HBV.
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