| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Ampicillin |
| Cas number | 69-53-4 |
| Apperance | White powder |
| MF | C16H19N3O4S |
| MW | 349.405 |
Ampicillin is well absorbed after administration. Normal individuals take 0.5g and 1g orally on an empty stomach, and reach peak blood drug concentrations of 5.2 μ g/mL and 7.6 μ g/mL after 2 hours, respectively; Inject 0.5g intramuscularly and reach the peak blood concentration of approximately 12 μ g/mL within 0.5-1 hour; The blood drug concentrations at 15 minutes and 4 hours after intravenous injection of 0.5g were 17 μ g/mL and 0.6 μ g/mL, respectively. After intramuscular injection of 10mg/kg and 25mg/kg in newborns and premature infants, the blood drug concentration reached its peak at 20 μ g/mL and 60 μ g/mL, respectively, 1 hour later. The drug is widely distributed in the body after absorption. Elevated drug concentrations in pleural and peritoneal effusion, joint cavity effusion, aqueous humor, and breast milk. The concentration of ampicillin in bile is several times higher than that in blood; The concentration of bronchial secretions in patients with pulmonary infections is 1/50 of the blood drug concentration during the same period; The drug concentration in the serum of pregnant women is significantly lower than during pregnancy. Ampicillin can penetrate the placental barrier and maintain a certain blood concentration in amniotic fluid. Ampicillin has a low ability to penetrate normal meninges, and normal cerebrospinal fluid contains only a small amount of the drug. However, the drug concentration increases significantly during meningeal inflammation. The distribution volume of ampicillin is 0.28L/kg, and the protein binding rate is 20% to 25%.
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