Antibiotic CAS 1264-72-8 Colistin Sulfate Powder Colistin

• Customization: Available
• CAS No.: 1264-72-8
• Formula: C52h100n16o17s
• Model NO.: QS- Colistin Sulfate
• EINECS: 215-034-3
• Packaging Material: Negotiable
• Storage Method: Normal
• Shelf Life: 2 Years
• Nutrient Composition: Colistin Sulfate
• Resource: Colistin Sulfate
• Product Name: Colistin
• Name: Colistin Powder
• Assay: HPLC 99%
• CAS: 1264-72-8
• Appearance: White Powder
• Color: White
• Mf: C53h102n16o17s
• MW: 2801.27
• Melting Point: 200-220 C
• Boiling Point: 1536.8
• Test Method: HPLC
• Grade: Veterinary Grade
• Application: Antibiotics
• Specific: COA
• Stability: Degrades in Acidic/Alkaline Conditions
• Transport Package: Negotiable
• Specification: 99%
• Trademark: QS
• Origin: Shaanxi Xi′an
• Production Capacity: 5000kg/Month

Product Description

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Antibiotic CAS 1264-72-8 Colistin Sulfate Powder Colistin

Product Description

Product Detials

Product Name	Colistin Sulfate
Apperance	White to off-white powder
CAS	1264-72-8
MF	C53H100N16O13
MW	1155.4

Colistin sulfate is a polymyxin-class antibiotic derived from Bacillus polymyxa, primarily used as a last-resort treatment for multidrug-resistant (MDR) Gram-negative infections. Chemically, it consists of a cyclic polypeptide with a fatty acid tail, formulated as a mixture of colistin A (polymyxin E1) and colistin B (polymyxin E2). The sulfate salt form enhances solubility for clinical use.

Application&Function

 1.Spectrum of Activity
Gram-negative pathogens:

Pseudomonas aeruginosa (MDR/XDR strains).
Acinetobacter baumannii, Klebsiella pneumoniae (carbapenem-resistant).
Ineffective against: Gram-positives, anaerobes, and Proteus/Serratia spp.
2. Clinical Applications
MDR Infections: Pneumonia, bacteremia, UTIs (IV/nebulized).
Cystic Fibrosis: Nebulized colistin for chronic Pseudomonas colonization.
Selective Gut Decontamination: Oral form for ICU patients (controversial).
3. Pharmacokinetics
Absorption: Poor oral bioavailability (IV/nebulized preferred).
Distribution: Limited CNS penetration; accumulates in kidneys/lungs.
Excretion: Renal (dose adjustment required for CKD).
4. Advantages
Last-Line Defense: Effective against carbapenemase-producing strains.
Synergy: Combines well with carbapenems/fosfomycin for enhanced killing.

Specification

Certificate of Analysis