| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Negotiable |
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| Product Name | Ampicillin |
| Apperance | white powder |
| CAS | 69-53-4 |
| MF | C16H19N3O4S |
| MW | 349.40 |
Manufacturing method
First, the side chain carboxylic acid of D (-) -phenylglycine is treated with the chlorinating agent PCI5. It is made into acyl chloride and then condensed with 6-APA to obtain it. water were added to the reaction tank. When the temperature was cooled to -5- 10ºC, 6-APA was added, followed by the addition of hydrochloride. After the reaction for 0.5 hours, the pH was adjusted to 3.5 with 10% .For the water intake layer, adjust the pH value to approximately 3.0 with 10% water. Decolorize with activated carbon and filter. The filtrate is then adjusted with water to make the pH 4.8. Let it stand, then filter it, and vacuum dry it at a temperature below 40ºC to obtain the product.
Clinical application
Ampicillin, also known as ampicillin or ampicillin, is less effective against most Gram-positive bacteria than penicillin. However, it has a strong effect on most Gram-negative bacteria, such as Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella and Pasteurella, etc. It is similar to or slightly stronger than chloramphenicol and tetracycline, but its toxic effect is less than that of chloramphenicol and tetracycline. It is ineffective against drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Ampicillin is widely used for pulmonary and urethral infections in humans and animals caused by sensitive bacteria, as well as certain infections caused by Gram-negative bacilli, such as human meningitis and endocarditis. Foal and calf pneumonia, bovine pasteurellosis, pneumonia, mastitis, porcine infectious pleuropneumonia, pullorum disease, avian typhoid fever, etc. Ampicillin is prone to interference and decomposition by the β -lactamase produced by bacteria, thereby reducing its therapeutic effect. Clinically, it is often used in combination with the artificially synthesized β -lactamase inhibitor - sulbactam to increase its synergistic effect, which not only improves its antibacterial activity but also expands its antibacterial spectrum. In addition, ampicillin, when used in combination with aminoglycoside antibiotics, also has a synergistic effect and can enhance the therapeutic effect.
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