Medical Grade Pharmaceutical Oxolinic Acid Raw Material Oxolinic Acid
Product Description
Product Details
| Product name |
Oxolinic Acid |
| Cas number |
14698-29-4 |
| Apperance |
White to pale yellow crystalline powder |
| MF |
C13H11NO5 |
| MW |
261.23 |
Oxolinic acid is a synthetic quinolone antibiotic primarily used in veterinary medicine and aquaculture to treat bacterial infections caused by Gram-negative pathogens. It works by inhibiting bacterial DNA gyrase, thereby preventing DNA replication and transcription. Oxolinic acid is effective against diseases such as furunculosis in fish and certain enteric infections in animals. However, its use is often regulated due to concerns about antibiotic resistance and environmental impact. Proper dosage and adherence to withdrawal periods are essential to ensure food safety and minimize ecological risks.
Application&Function
Toxicity
The acute oral LD50 of the active drug for rats is 630mg/kg (male) and 570mg/kg (female). For male mice, the acute oral LD50 is 2200mg/kg, and for female mice, it is 1450mg/kg. The acute percutaneous LD50 of rats is greater than 2000mg/kg, which has no irritating effect on the skin but a mild irritating effect on the eyes. No sensitizing effect. The ineffective dose in the 2-year feeding experiment for rats was 100-300mg/kg. Animal experiments showed no teratogenic, carcinogenic or mutagenic effects. When used in the conventional way, it has no effect on fish. For carp, LC50 is 10mg/L (48 hours).
Purpose
Quinolinone fungicides, used in rice seed treatment, are regarded as the first fungicide with remarkable efficacy against the difficult-to-treat rice blight bacterial disease (seedling spoilage disease). Before sowing, seed treatment with chemical agents can inhibit the occurrence of seedling breakage and corruption caused by bacterial blight. After transplanting healthy seedlings, the occurrence of bacterial blight can be prevented. The mechanism of action is that it has a wide range of antibacterial activity against Gram-negative bacteria, but its activity against Gram-positive bacteria is weak and it has no activity against fungi. By inhibiting the synthesis of DNA, it hinders the division and proliferation of bacteria. In the bacterial body, an enzyme for reverse hypercurling is introduced into the hypercoiled structure of DNA. This agent can bind to subgroup A of this enzyme, thereby suppressing its function and preventing DNA replication, which will soon lead to death. Soak the seeds in 1000g/mL for 24 hours, 1000g/mL for 10 minutes, or coat the seeds with 20% wettable powder at 0.5% of the seed mass, achieving a control effect of over 97%. This product can also be used to prevent and control rice grain rot, potato black cavity disease, soft rot, fire blight and similar diseases. If 300-600g of the active ingredient /hm2 is sprayed on the leaves during the rice heading stage, it can prevent and control rice grain rot. Foliar spraying at a rate of 300 to 600 grams of the active ingredient per hectare can prevent and control fire blight and soft rot in apples and pears. It also has a very good protective and therapeutic effect on soft rot of Chinese cabbage.
Production method
The preparation of methylene dioxyaniline involves nitration and reduction of methylene dioxybenzene to obtain methylene dioxyaniline.The synthesis of quinazone: Methylene dioxylaniline and diethyl ethoxylene malonate were heated and reacted at 80-90ºC for 3 hours, then cycled in xylene. Subsequently, n-alkylation was carried out in DMF solvent with eiodithan at 70-75ºC. The mixture was diluted with water and refluxed for 3-4 hours The hydrolysis products are acidified to form quinazone.
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