Pharmaceutical Raw Hydroxyzine Powder High Purity Hydroxyzine
Product Description
Product Details
| Product Name |
Hydroxyzine |
| Appearance |
Hydroxyzine Powder |
| Assay |
>99% |
| MW |
374.90428 |
| MF |
C21H27ClN2O2 |
| Melting point |
190C |
| Boiling point |
220C |
Hydroxyzine is a antihistamine that acts as an orally active histamine H1 receptor and serotonin antagonist. Hydroxyzine has anti anxiety effects and can be used in research on generalized anxiety disorder.
Application&Function
The drug action of Hydroxyzine:
1.Antiallergic effect: Hydroxyzine can inhibit serotonin release caused by choline, thereby reducing allergic reactions. For example, in pre processed bladder sections, Hydroxyzine (10 μ M) can inhibit choline (10 μ M) - induced serotonin release by 34%, while 1 μ M and 0.1 μ M Hydroxyzine inhibit by 25% and 17%, respectively.
2.Immunomodulatory effect: Hydroxyzine can inhibit the development and severity of experimental allergic encephalomyelitis (EAE), an autoimmune disease similar to multiple sclerosis in humans. In addition, it can also reduce the activation of brain mast cells associated with EAE.
3.Drug metabolism effects: Hydroxyzine can alter the transport and metabolism of certain drugs. For example, it can increase the transport of etoposide in the ileal inversion sac and reduce its excretion in the duodenum and ileum. In addition, it can enhance the excretion of Rhodamine 123 into the intestinal lumen.
4.Analgesic effect: Although Hydroxyzine itself shows less direct analgesic activity, it can significantly enhance the analgesic effect of . For example, intraperitoneal injection of Hydroxyzine at a dose of 50 mg/kg enhanced the tail twitching test response of mice to , while a dose of 12.5 mg/kg reduced the anti analgesic effect of .
Specification
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