| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Negotiable |
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| Product Name | Triclabendazole |
| Appearance | White to off-white powder |
| Assay | ≥98.0% |
| MF | C14H9CL3N2O2S |
| MW | 381.66 g/mol |
Other benzimidazole drugs, such as albendazole, have limited efficacy against liver flukes, while trichlorobendazole is the only highly effective anti liver fluke drug.
Human use:
Liver fluke disease (acute and chronic infections).
Paragonimiasis (some cases, such as infection with Paragonimus westermani).
Animal use:
Treatment of liver fluke infection in ruminant animals such as cattle and sheep.
Triclabendazole can be metabolized into many compounds depending on the route of administration, with peak blood concentrations occurring at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone). Triclabendazole and any other metabolites were not detected in the plasma. Triclabendazolesulphoxide inhibits the transport of secretory tissues from the cell body to the surface, and has inhibitory effects on the formation of the Golgi complex in the cell body, occurring in the movement of the cytoplasm connecting to the cell body and from the base to the top of the cell body. The binding site of β - Chemicalbook microtubule protein molecule to colchicine has been used for the evaluation of Triclabendazole related activity. Triclabendazole 10mg/kg was administered intraperitoneally to goats, and the only metabolites of Triclabendazole (TCBZ) present in the plasma were TCBZsulphoxide (TCBZ-SO) and TCBZsulphone, which had maximum concentrations (greater than 13mg/mL) at 18 and 36 hours, respectively. Triclabendazole metabolites specifically bind to plasma albumin, which has a significant impact on the blood concentration of TCBZ metabolites and the contact response of liver flukes. Triclabendazole (40mg/kg) can kill 99% of adult flukes in rats.
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