CAS 2627-69-2 Acadesine Powder Raw Material Acadesine
Product Description
Product Details
| Product Name |
Acadesine |
| Appearance |
White Powder |
| Assay |
99% |
| MW |
258.23126 |
| MF |
C9H14N4O5 |
Acadesine is a nucleoside analogue that can enter the nucleoside library and significantly increase adenosine levels during ATP breakdown.
(Acadesine, NSC105823, AICA Riboside) is an activator of , causing ZMP accumulation and simulating the stimulating effect of AMP on and K. (Acadesine) can induce mitochondrial autophagy. Phase 3. In the mouse K562 cell xenograft model, Acadesine (50 mg/kg) significantly reduced tumor formation. Acadesine (10 mg/kg) causes an increase in the amount of fluid required for stable hemodynamics in pigs. In pigs, Acadesine (10 mg/kg) inhibits LPS induced protein permeation in pulmonary capillaries, suppresses peak inspiratory pressure at constant respiratory volume, and increases ineffective ventilation chambers.
Application&Function
purpose
Treatment of acute lymphoblastic leukemia
As an activator of purine nucleoside analogs and AMP activated protein kinases, acadixin can be used to treat acute lymphoblastic leukemia.
cardioprotection
Adenosine modulators (ARAs) have been considered to have therapeutic potential in myocardial ischemia, and acaricin, as the prototype of adenosine modulators, has been reported to have cardioprotective effects. Experiments in pigs have shown that Acadesine (10mg/kg) can inhibit LPS induced protein permeation in pulmonary capillaries, suppress peak inspiratory pressure at constant respiratory volume, and prevent an increase in ineffective ventilation chambers; Acadesine (10mg/kg) can also cause an increase in the amount of fluid required for stable hemodynamics in pigs.
Inducing cell apoptosis
Acadixin dose dependently induces apoptosis in B-CLL cells, reducing the cellular activity of B-CLL cells from typical patients, as well as inducing caspase activation and cytochrome C release from mitochondria. Its uptake and phosphorylation are necessary for inducing apoptosis and activating in B-CLL cells.
Specification
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