| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
Still deciding? Get samples of $ !
Request Sample
|
Suppliers with verified business licenses
| Product Name | Clindamycin Hydrochloride |
| Apperance | white crystalline powder |
| CAS | 21462-39-5 |
| MF | C18H34Cl2N2O5S |
| MW | 461.44 |
Precautions
Clindamycin should be administered intravenously for severe infections, especially anaerobic infections. It is contraindicated to administer large doses rapidly. It should not be combined with ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate or magnesium sulfate in the same container. It should not be used in combination with macrolides such as erythromycin, drynamycin and mediamycin, or chloramphenicol. It should not be used in combination with sodium sulfadiazine or vitamin C. It has a synergistic effect with gentamicin. When combined with TMP, it can improve clinical treatment and reduce adverse drug reactions. This product can be successfully combined with antibacterial drugs such as amikacin, tobramycin, methicillin, cephalosporins and fluoroquinolones. The most serious adverse reaction is pseudomembranous enteritis, which can occur during treatment or several weeks after medication. Once it occurs, vancomycin can be used for treatment. Other gastrointestinal reactions include nausea, distension, anorexia, diarrhea, etc., with an incidence rate of 2% to 20%.
Clinical application
At present, clindamycin hydrochloride is mainly used in clinical practice to treat infections caused by Gram-positive cocci and various anaerobic bacteria, as well as infections of joints, bone marrow, respiratory tract and skin and soft tissues, tonsillitis, pharyngitis, pneumonia, and various infections such as acne, gynecological inflammation, endocarditis and empyema. Acne vulgaris is a kind of skin disease frequently seen in clinical practice. The causes of its onset have been studied, mainly due to infection by aerobic bacteria and anaerobic bacteria, among which the anaerobic bacteria are Propionibacterium acnes. According to various data, the above-mentioned pathogenic bacteria are all within the antibacterial spectrum of clindamycin. The use of clindamycin gel to treat common acne can achieve a cure rate of 93.3%. 2% Clindamycin Hydrochloride Cream (oil-in-water type) can be used to treat vaginitis. It has the advantages of good effect, no irritation and high local drug concentration, and can be used to treat bacterial vaginitis.
Clindamycin hydrochloride is easily soluble, has a high distribution coefficient in the body, has few adverse reactions, and is less affected by daily diet. It can be made into various dosage forms such as tablets, injections, liniments, gels, vaginal effervescent tablets, etc. However, the biological half-life of this drug is short, approximately 3 hours. Therefore, it is administered 3 to 4 times a day. To reduce the frequency of administration, maintain the stability of blood drug concentration, improve patient compliance, and enhance the therapeutic effect, there have been relevant reports on sustained-release and controlled-release preparations.
){kind=link}