Best Selling Hydroxyurea Pharmaceutical Hydroxyurea
Product Description
Product Details
| Product Name |
Hydroxyurea |
| Appearance |
Hydroxyurea Powder |
| Assay |
>99% |
| MW |
76.05466 |
| MF |
CH4N2O2 |
| Melting point |
142C |
| Density |
1.457 |
Hydroxyurea appears as white needle-like crystals with a melting point of 70-72°C (decomposition) or 141°C upon decomposition. It is soluble in water and hot ethanol, slightly soluble in cold ethanol, and insoluble in ethyl ether and benzene. This compound is unstable when exposed to water or heat and is odorless and tasteless. As an anticancer medication, hydroxyurea is primarily used to treat chronic myelogenous leukemia. It exerts its therapeutic effects by inducing the production of a molecule within bacteria that is toxic to them, leading to their destruction.
Application&Function
Hydroxyurea is an antimetabolite anticancer drug that primarily targets proliferating cells during the G1 and S phases of the cell cycle, delaying the G1/S interface. It is a cell cycle-specific agent with significant antitumor properties. The drug works by inactivating ribonucleotide reductase through the formation of free nitric oxide, which binds to tyrosine residues at the enzyme's active site. This inhibition prevents the synthesis of deoxynucleotides, essential for DNA replication and repair, thereby halting the growth of cancer cells.
Hydroxyurea is clinically used in the treatment of chronic myelogenous leukemia, metastatic ovarian cancer, primary squamous cell carcinoma of the head and neck, and refractory psoriasis. As an antitumor drug, it plays a crucial role in managing these conditions by selectively targeting rapidly dividing cells and disrupting their proliferation. Its mechanism of action and therapeutic applications make it a valuable option in oncology and dermatology.
Specification
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