Pharmaceutical CAS 137-58-6 Lidocaine HCl Lidocaine
Prouct Description
Product Details
| Product Name |
Lidocaine |
| Apperence |
White Crystalline Powder |
| CAS |
137-58-6 |
| MF |
C14h22n2o |
| MW |
234.34 |
Lidocaine (English: Lidocaine) is a local anesthetic and antiarrhythmic drug. It is a derivative of but does not contain the hallucinogenic and addictive components of . Lidocaine hydrochloride is a white crystalline powder that is highly soluble in water. Its toxicity is comparable to that of procaine, but it has a strong and long-lasting local anesthetic effect and good surface penetration. It can be injected or used for surface anesthesia. Lidocaine is an excellent local anesthetic. It usually takes effect one to three minutes after application and the effect lasts for one to three hours. Used for treating oral ulcers. As a drug for arrhythmia, it is not often used now because some people are worried that it may have long-term side effects. A few people are allergic to lidocaine. It was used to treat arrhythmia in 1963 and is currently a drug for the prevention and treatment of acute myocardial infarction and various heart diseases complicated with rapid ventricular arrhythmia. It is the first choice of drug for ventricular premature beats, ventricular tachycardia and ventricular tremor in acute myocardial infarction.
Application&Function
Purpose
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltages and dependencies. Lidocaine reduces the growth, migration and invasion of gastric cancer cells by regulating the expression of miR-145 and further inhibiting the MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative that can be used to study ventricular arrhythmias.
Production method
It is obtained by acylation and amination of 2, 6-dimethylaniline. 1. Acylation: Dissolve 2, 6-dimethylaniline in anhydrous benzene, cool to below 28ºC, and slowly add chloroacetyl chloride while stirring. Keep the temperature below 30ºC. After addition, stir and react for 1 hour, then heat and reflux for 8 hours. Cooling crystallization, filtration and drying were carried out to obtain 2, 6-dimethylchloroacetaniline. Yield: 75%. 2. Amination: Add the above-mentioned 2, 6-dimethylchloroacetaniline to benzene, then add diethylamine, stir, heat and reflux for 7 hours. After recovering most of the benzene, it was cooled and crystallized, filtered, and the crystals were washed with benzene. Combine the benzene liquid, extract with 10% hydrochloric acid, add activated carbon to the extract for decolorization, and then filter. The filtrate was adjusted to a pH of 10 with a 10% sodium hydroxide solution to precipitate crystals. It was then spun and filtered, washed with water until neutral, and lidocaine was obtained. After recrystallization, the salt formed with hydrochloric acid is lidocaine hydrochloride. The yield of the amination reaction was 76%.
Specification
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