Factory Supply Raw Material Cisapride Pharmaceutical Cisapride
Product Description
Product Details
| Product name |
Cisapride |
| Cas number |
81098-60-4 |
| Apperance |
White powder |
| MF |
C23H29ClFN3O4 |
| MW |
465.95 |
Cisapride, an inorganic compound with chemical formula C23H29ClFN3O4, belongs to benzoamide derivative and is a novel whole-gastrointestinal mototropic drug.
use
1. Gastrointestinal motility drugs can strengthen and coordinate gastrointestinal movement, prevent food retention and reflux, and thus have antiemetic effect.
2, there is a strong stabilizing effect, can be used as a psychiatric treatment. There is no blocking of dopamine receptors and direct stimulation of cholinergic receptors, so there are no corresponding side effects.
3, for gastroparesis, gastro-esophageal reflux, upper digestive tract discomfort, chronic constipation, false intestinal obstruction, etc.
Application&Function
pharmacokinetics
1, after oral absorption is rapid and thorough, the peak concentration of blood drugs is reached within 1 to 2 hours, the half-life is 10 hours, the oxidation of dehydrocarbylation and aromatic hydroxylation are widely metabolized, almost all metabolites are approximately equal excreted by feces and urine, and the milk excretion during lactation is very small.
2, the absolute bioavailability of oral administration is about 40%. The blood concentration increases proportionally with the oral dose (5 to 20mg).
3. In the stable state, the blood concentration before taking orally 5mg three times a day and 10mg three times a day fluctuated between 10 ~ 20ng/mL, 30 ~ 60ng/mL, 20 ~ 40ng/mL and 50 ~ 100ng/mL, respectively, in the morning and evening.
4. Pharmacokinetics and steady-state plasma concentration were independent of treatment duration, and the combination of cimetidine slightly increased oral bioavailability. It extensively binds to plasma proteins (97.5%).
Specification
About US
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