Bulk CAS 317-34-0 Aminophylline Raw Material Aminophylline
Product Description
Product Details
| Product Name |
Aminophylline |
| Appearance |
White Powder |
| Assay |
99% |
| MF |
C16H24N10O4 |
| MW |
420.42600 |
Aminophylline is a complex of theophylline and (theophylline accounts for 75% -82%), with significantly increasing its water solubility. As a non selective phosphodiesterase (PDE) inhibitor and adenosine receptor antagonist, it exerts potent bronchodilator effects by increasing intracellular cAMP concentration and blocking adenosine mediated bronchoconstriction. It is clinically used to alleviate asthma, chronic obstructive pulmonary disease (COPD), and acute bronchospasm. The treatment window is narrow, and excessive use can easily cause toxic reactions such as arrhythmia and epilepsy, requiring strict monitoring of blood drug concentration. Its aqueous solution is unstable and needs to be stored in a sealed environment away from light. Prolonged storage can easily precipitate theophylline crystals.
Application&Function
The drug properties of Aminophylline are as follows:
1. Basic attributes
Chemical composition: A complex formed by theophylline and , with theophylline content ranging from 75% to 82% and content ranging from 12.3% to 13.8%. The addition of significantly improved water solubility.
Physical properties: White or light yellow particles/powder, slightly odor, bitter taste; Exposure to air can easily absorb carbon dioxide and precipitate theophylline.
Solubility: Easy to dissolve in water (80 mg/mL), slightly soluble in DMSO (50 mg/mL), almost insoluble in ethanol or .
2. Pharmacological effects
Mechanism of action:
As a competitive, non selective phosphodiesterase (PDE) inhibitor, it inhibits PDE activity (IC50 of 0.12 mM), thereby increasing intracellular cAMP levels and relaxing smooth muscles.
It is also an adenosine receptor antagonist that blocks adenosine mediated bronchoconstriction.
Biological activity: exerting bronchodilator effects through a dual mechanism, mainly used to alleviate respiratory obstruction symptoms in asthma and chronic obstructive pulmonary disease (COPD).
3. Storage and stability
Storage conditions: Powder form is recommended to be stored at -20 ° C (3 years), and solution should be stored at -80 ° C (6 months). The aqueous solution is alkaline and prone to turbidity after prolonged storage.
4. Application and Precautions
Indications: Clinically used for the treatment of respiratory diseases such as asthma and COPD, especially for the relief of acute bronchospasm.
Safety: Strict dosage control is required, as excessive dosage may cause adverse reactions such as arrhythmia and epilepsy.
The above properties combine key information from its chemistry, pharmacology, and clinical applications.
Specification
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