| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Vancomycin |
| Apperance | White to off-white powder |
| CAS | 1404-90-6 |
| MF | C66H75Cl2N9O24 |
| MW | 1449.25 |
Indications
It is limited to systemic infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and intestinal and systemic infections caused by Clostridium difficile. People allergic to penicillin cannot use penicillins or cephalosporins. For patients with severe staphylococcal infections who have not responded to the above antibiotics, vancomycin can be selected. This product is also used for the treatment of Enterococcal endocarditis and Corynebacterium (Corynebacterium diphtheriae) endocarditis in individuals allergic to penicillin. Treatment of arteriovenous shunt infections caused by Staphylococcus in hemodialysis patients who are allergic to penicillin and those who are not.
In vitro study
Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da. Vancomycin is a unique glycopeptide and has no relation to the structure of any currently available antibiotics. It also has a unique mode of action, inhibiting the second stage of cell wall synthesis in sensitive bacteria. Vancomycin is active against a large number of Gram-positive bacteria, such as Staphylococcus aureus and Staphylococcus. Epidermococcus, Streptococcus agalactiae, Streptococcus bovis, Streptococcus mutans, Streptococcus aureus, Enterococcus.
In vivo study
Vancomycin is administered intravenously. The standard infusion time is at least one hour to minimize the adverse reactions related to infusion as much as possible. Among the subjects with normal creatinine clearance rate, the α -distribution period of vancomycin was 30 min to 1 h, the β -elimination half-life was 6 to 12 h, and the distribution volume was 0.4 to 1 L/kg. The binding rate of vancomycin to proteins is between 10% and 50%. The factors influencing the overall activity of vancomycin include its tissue distribution, inoculation amount and protein binding. Vancomycin treatment of infected mice was associated with improved clinical, diarrheal and histopathological scores as well as survival rates during treatment.
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