Veterinary Drug CAS 1264-72-8 Colistin Sulfate Purity Colistin Sulfate
Product Description
Product Details
| Product Name |
Colistin Sulfate |
| Appearance |
white Powder |
| Assay |
>99% |
| MW |
1253.53 |
| MF |
C52H100N16O17S |
Colistin Sulfate is an aminoglycoside antibiotic produced by fermentation of Streptomyces, which interferes with protein synthesis by irreversibly binding to the 30S ribosomal subunit of bacteria. It has broad-spectrum antibacterial activity against Gram negative bacteria (such as Escherichia coli and Klebsiella) and some Gram positive bacteria (such as methicillin-resistant Staphylococcus), but has weak effects on streptococci and anaerobic bacteria. Clinically, it is mainly used to treat intestinal infections, skin and eye infections, and as an adjuvant therapy for preoperative intestinal preparation or hepatic coma to reduce the absorption of intestinal microbiota metabolites. In addition, it is also used in scientific research fields such as gene screening and antibiotic mechanism research. It should be noted that neomycin sulfate may cause ototoxicity and nephrotoxicity, and should be strictly used according to medical advice. When storing, it should be sealed and kept away from light, and stored at low temperatures and moisture to ensure stability.
Application&Function
The pharmacological effects of Colistin Sulfate
1, Antibacterial effect and mechanism
Mechanism of action
By combining lipopolysaccharides (LPS) and phospholipids in the outer membrane of Gram negative bacteria, the integrity of the cell membrane is disrupted, leading to leakage of cell contents and bacterial death.
It has a rapid bactericidal effect on bacteria and develops drug resistance slowly.
Antibacterial spectrum
Highly effective against Gram negative bacteria, including:
Pseudomonas aeruginosa (Pseudomonas aeruginosa)
Escherichia coli, Salmonella, Shigella, Haemophilus influenzae
No significant activity against Gram positive bacteria and fungi.
2, Clinical application
Treatment of infectious diseases
Serious infections: sepsis, acute enteritis, urinary tract infections, etc.
Specific pathogen infections:
Infections caused by Pseudomonas aeruginosa (such as lung infections, burn infections);
Multidrug resistant Gram negative bacterial infections (in combination with other antibiotics).
Intestinal diseases
Treat intestinal infections caused by sensitive bacteria and inhibit gut microbiota metabolism to reduce toxin absorption.
3, Drug resistance research and scientific application
Research on Drug Resistance Mechanisms
Used to analyze the role of bacterial outer membrane permeability and lipopolysaccharides in drug resistance.
As a selector for Gram negative bacteria in microbiological research.
Environment and Public Health
Monitor the spread of antibiotic resistance genes in ecosystems.
4, Other uses
In the field of animal use:
Treatment of intestinal infections in livestock and poultry and growth promoting additives.
5, Safety and Precautions
Toxicity risk:
Long term or excessive use may lead to nephrotoxicity, and renal function needs to be monitored.
Clinical use must strictly follow the dosage and course of treatment.
The above information integrates the antibacterial mechanism, indications, and research value of sulfamethoxazole, covering its core roles in both medical and scientific fields.
Specification
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