| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Apigenin |
| Appearance | Yellow to off-white powder |
| Assay | 99% |
| MF | C15H10O5 |
| MW | 270.24 g/mol |
A plant flavonoid was found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. The inhibition of growth through cell cycle arrest and induction of apoptosis seems to be related to the induction of p53. The inhibitory effect on tumor promotion might be due to the inhibition of kinase activity and the resulting suppression of oncogene expression. The study also reported the inhibition of DNA re-ligation catalyzed by topoisomerase I and the enhancement of gap junction communication between cells by inhibiting PMA-mediated tumor promotion. It was also reported that the inhibition of DNA re-ligation catalyzed by topoisomerase I and the enhancement of gap junction communication between cells were achieved by inhibiting protein kinase C and the resulting suppression of oncogene expression.
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