Chemical Intermediate Dopamine Hydrochloride CAS 62-31-7 Dopamine
Product Description
Product Details
| Product Name |
Dopamine |
| Appearance |
Dopamine Powder |
| Assay |
>99% |
| MW |
189.64 |
| MF |
C8H12ClNO2 |
| Melting point |
248-250C(lit.) |
| Boiling point |
337.7C at 760 mmHg |
Dopamine hydrochloride is an adrenergic dopamine receptor agonist that appears as a white crystalline powder and is easily soluble in water. This drug promotes angiogenesis by activating D2 dopamine receptors and directly stimulates β - κ receptors to enhance myocardial contractility. It is mainly used clinically to treat hemorrhagic, cardiogenic, and septic shock, and can increase blood pressure, improve renal blood flow, and microcirculation. Its dosage form is sterile powder or solution for injection, which needs to be stored in the dark below 30 ° C to avoid oxidation and decomposition; When using, it is necessary to prepare and use it immediately, and strictly monitor blood pressure, heart rate, and urine output to prevent adverse reactions such as arrhythmia. This drug comprehensively regulates cardiovascular function and is one of the key drugs for hemodynamic support in critically ill patients.
Application&Function
The pharmacological effects of Dopamine can be summarized as follows:
1, Regulating effect of cardiovascular system
Anti shock
Suitable for toxic shock, cardiogenic shock, hemorrhagic shock, and central shock, especially for patients with renal insufficiency, reduced cardiac output, and already replenished blood volume, the effect is significant. It increases blood pressure and maintains organ perfusion by enhancing myocardial contractility and regulating peripheral vascular resistance.
Heart strengthening effect
By stimulating cardiac beta receptors to enhance myocardial contractility and increase cardiac output, it is used for the treatment of heart failure and cardiac dysfunction.
2, Regulation of renal function
It can dilate renal blood vessels, increase renal blood flow and glomerular filtration rate, promote urine production, and have a protective effect on patients with acute renal insufficiency.
3, Endocrine regulatory effect
Inhibiting prolactin secretion, clinically used to treat endocrine disorders such as hyperprolactinemia.
4, Neurotransmitter action
As a natural catecholamine, it participates in the regulation of angiogenesis by activating D2 dopamine receptors to mediate the endocytosis of receptor 2 (VEGFR2).
Specification
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