Pharmaceutical Material Gentamicin Veterinary Drug Gentamicin

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: QS-Gentamicin
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Crystalline Powder
• Purity: >99%
• Product Name: Gentamicin
• Name: Gentamicin Powder
• Appearance: White Crystalline Powder
• Color: White
• Store: Cool and Dry
• Grade: Pharmaceutical Grade
• CAS No: 1403-66-3
• Mf: C60h123n15o21
• MW: 1390.71
• Density: 1.3 g/cm3
• Assay: 99%
• Test Method: HPLC
• Specific: COA
• Application: Pharmaceutical
• Boiling Point: 669.4ºC at 760 Mmhg
• Transport Package: Negotiable
• Specification: Negotiable
• Trademark: QS-Gentamicin
• Origin: Shaanxi Xi′an
• Production Capacity: 2000kg/Month

Product Description

Pharmaceutical Material Gentamicin Veterinary Drug Gentamicin

Product Description

Product Details

Product Name	Gentamicin
Appearance	White Crystalline Powder
CAS NO	1403-66-3
MW	1390.71
MF	C60H123N15O21

Gentamicin is an aminoglycoside drug. Its mechanism of action is to act on ribosomes in bacteria, inhibit bacterial protein synthesis, and disrupt the integrity of bacterial cell membranes. Gentamicin can first passively diffuse through the extracellular membrane porin, and then enter the cell through the transport system and irreversibly bind to the separated 30S subunit of the ribosome, leading to the destruction of the A-site, and subsequently:
1. Prevent the correct localization tRNA at position A, especially by hindering the binding of methionine tRNA, thereby interfering with the assembly of functional ribosomes and inhibiting the formation of the 70S initiation complex.
2. Inducing incorrect matching of tRNA and mRNA code triplets, causing the 30S subunit of the intact ribosome to misread the genetic code, resulting in incorrect amino acid insertions into protein structures, leading to abnormal and non functional protein synthesis.
3. Obstructing the binding of termination factors to A-site prevents the release of synthesized peptide chains and hinders the complete dissociation of the 70S ribosome.
4. Obstructing the depolymerization and assembly process of multiple ribosomes, resulting in the depletion of ribosomes in bacteria. Gentamicin has strong antibacterial activity against Pseudomonas aeruginosa, Proteus (indole positive and negative), Escherichia coli, Klebsiella, Escherichia coli, Serratia, Shigella, Citrobacter, Neisseria, and Staphylococcus aureus (excluding methicillin-resistant strains). Gentamicin is ineffective against Streptococcus (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, etc.), anaerobic bacteria (Bacteroidetes), Mycobacterium tuberculosis, Rickettsia, viruses, and fungi.

Application&Function

After intramuscular injection, absorption is rapid and complete. After local flushing or application, a certain amount can also be absorbed on the surface of the body. After absorption, it is mainly distributed in extracellular fluid, with 5-15% of it being redistributed to tissues and accumulating in renal cortical cells. This product can pass through the placenta. The distribution volume is 0.2-0.25L/kg (0.06-0.63L/kg). The drug concentration in urine is high. The drug content in bronchial secretions, cerebrospinal fluid, subarachnoid space, eye tissue, and aqueous humor is low. Low or very low protein binding rate. The peak blood drug concentration is reached 30-60 minutes after intramuscular injection or intravenous infusion. The peak blood drug concentration (μ g/ml) in adults after intramuscular injection is generally four times the intramuscular dose based on body weight (mg/kg). After intravenous infusion, it can reach 4-6 μ g/ml, and in infants, it can reach 3-6 μ g/ml after a single dose of 2.5mg/kg; Patients with fever or extensive burns may experience a decrease in blood drug concentration. T1/2 is 2-3 hours for adults and 40-50 hours for those with renal function decline. Patients with fever, anemia, severe burns, or those who receive combination therapy with carbenicillin may have a shortened T1/2; But there are significant differences among different patients in gynecology, surgery, and burns. Children have a T1/2 of 5 to 1.5 hours, with lighter weight having a longer T1/2. This product is not metabolized in the body and is excreted through glomerular filtration. The concentration in urine can exceed 100 μ g/ml, and 50-93% is excreted within 24 hours. For newborns born within 3 days, 10% will be excreted within 12 hours of administration; Newborns born between 5-40 days old should excrete 40% within 12 hours of administration. Hemodialysis and peritoneal dialysis can clear a considerable amount of medication from the blood, significantly reducing T1/2.

Specification