Best Price Medicine Nystatin Antifungal Antibiotic Nystatin
Product Description
Product Details
| Product Name |
Nystatin |
| Appearance |
yellow Powder |
| Assay |
>99% |
| MW |
926.0949 |
| MF |
C47H75NO17 |
Nystatin is a polyene antifungal agent primarily used for the treatment of fungal infections. The chemical name of Nystatin is nystatin, also known as mycophenolate mofetil, nystatin, etc. Nystatin mainly exerts antibacterial effects by increasing the permeability of cell membranes and is commonly used to treat Candida infections in the mouth and esophagus.
Application&Function
The pharmacological effects of Nystatin
1, Antifungal effect and mechanism
Mechanism of action
As a polyene antifungal antibiotic, it binds to ergosterol in the fungal cell membrane to form transmembrane pores, leading to the leakage of ions and small molecules inside the cell, ultimately damaging the integrity of the cell membrane and killing the fungus.
It can increase the permeability of the plasma membrane to monovalent ions (such as chloride ions) and interfere with fungal metabolic activities.
2, Clinical application
Infection treatment
Skin infections: diaper rash, candidal dermatitis, etc.
Mucosal infections: gingivitis, esophageal candidiasis, candidal vulvovaginitis.
Preventive application: Prevention of Candida infection in immunocompromised patients (such as after chemotherapy or organ transplantation).
3, Research and Molecular Biology Applications
Mechanism research
Used to study the role of cholesterol in lipid raft aggregation and inhibit cell apoptosis induced by drugs such as oxaliplatin.
Exploring the membrane ion channel function and fungal resistance mechanism as a tool drug.
Anti tumor and anti angiogenesis
By enhancing the uptake of specific drugs (such as endonucleases) in tumor blood vessels, the anti angiogenesis and anti-tumor effects are improved.
Cell culture
Prevent fungal contamination in cell culture.
Specification
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