Dolutegravir is an HIV integrase inhibitor, which interferes with the relevant enzymes required for HIV reproduction. It is taken once a day. The drug is applicable to adults infected with HIV who have not taken HIV antiretroviral therapy drugs, and adults infected with HIV who have previously received other HIV integrase inhibitors. Clinical doctors can order Dolutegravir or other antiretroviral drugs for children aged 12 years or older and weighing at least 40 kilograms. These patients are in the early stages of treatment or in the midst of treatment and have not previously used any other HIV integrase inhibitors. People living with HIV need personalized treatment programmes to meet their situation and their needs.
Application&Function
Mechanism of Action
The main mechanism of action of Dolutegravir is by inhibiting the activity of HIV integrase. Integrating enzymes are key enzymes in the HIV lifecycle, responsible for integrating the virus's genetic material into the host cell's DNA, thereby promoting virus replication. Dolutegravir effectively inhibits virus replication by binding to integrase, preventing the binding of viral DNA to host DNA.
Drug efficacy
Dolutegravir is very effective in the treatment of AIDS. Clinical studies have shown that patients treated with this drug can rapidly reduce their HIV viral load to undetectable levels. Due to its good tolerance, many patients can achieve long-term viral suppression when receiving Dolutegravir treatment, which is of great significance for improving patients' quality of life and prolonging their lives.
Drug interactions
Dolutegravir may interact with other drugs when used simultaneously. For example, enzyme inducers may increase the activity of CYP3A4 enzyme, thereby reducing the plasma concentration of Dolutegravir; Enzyme inhibitors may lead to an increase in plasma concentration of Dolutegravir. Therefore, when patients use Dolutegravir and other medications simultaneously, it may be necessary to adjust the dosage to ensure its efficacy and safety.
Specification
Factory Supply CAS 1051375-16-6 Dolutegravir Sodium Pharmaceutical Dolutegravir
){kind=link}